Spicy Southern Chicken Spaghetti Casserole

Name: Spicy Southern Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 4 servings
Ingredients: 2 cups cooked spaghetti; 1 lb cooked chicken, shredded; 1 can diced tomatoes with green chilies; 1 cup cream of mushroom soup; 1 cup shredded cheese; 1/2 cup sour cream; 1 tsp paprika; 1 tsp cayenne pepper; Salt and pepper to taste; 2 tablespoons olive oil

Highlighted under: Comfort Food

This Spicy Southern Chicken Spaghetti Casserole is a comforting dish packed with zesty flavors and creamy goodness. Combining tender chicken, al dente pasta, and a spicy kick, this casserole is perfect for busy weeknights or as a crowd-pleasing potluck dish. Bake it up for a satisfying meal that brings the warmth of Southern cooking to your dinner table.

Created by

Olivia Hayes

Last updated on 2025-11-13T08:43:47.719Z

This dish combines the robust flavors of Southern cuisine with the comforting qualities of a casserole. Perfect for family gatherings or a cozy dinner at home.

A Taste of the South

Southern cooking is beloved for its rich flavors and comforting textures, and this Spicy Southern Chicken Spaghetti Casserole embodies that essence perfectly. The combination of tender chicken and al dente pasta drenched in a creamy, spicy sauce makes for a dish that’s not only satisfying but also incredibly tasty. With every bite, you’ll experience a delightful blend of flavors that take you on a culinary journey to the heart of the South.

What sets this casserole apart is its versatility. You can adjust the spice level by varying the amount of cayenne pepper to suit your personal taste. Additionally, it can be made ahead of time and stored in the refrigerator, making it a convenient option for serving family or guests. Simply reheat it in the oven, and you’ll have a delicious home-cooked meal ready in no time.

Perfect for Any Occasion

Whether you’re preparing for a busy weeknight dinner or looking for a delicious dish to share at a potluck, this casserole is an ideal choice. The recipe is designed to feed a crowd, ensuring that everyone leaves the table satisfied. It’s also a great way to use leftover chicken, turning what might be a mundane meal into something spectacular and flavorsome.

Furthermore, this Spicy Southern Chicken Spaghetti Casserole pairs beautifully with a simple side salad or some garlic bread. Your family and friends will appreciate the effort you put into making a crowd-pleaser that captures the warmth and hospitality characteristic of Southern cuisine.

Ingredients

For the Casserole

2 cups cooked spaghetti
1 lb cooked chicken, shredded
1 can diced tomatoes with green chilies
1 cup cream of mushroom soup
1 cup shredded cheese
1/2 cup sour cream
1 tsp paprika
1 tsp cayenne pepper
Salt and pepper to taste
2 tablespoons olive oil

Mix well to ensure all ingredients are combined.

Instructions

Prepare the Oven

Preheat your oven to 375°F (190°C).

Combine Ingredients

In a large mixing bowl, combine the cooked spaghetti, shredded chicken, diced tomatoes, cream of mushroom soup, shredded cheese, sour cream, paprika, cayenne pepper, salt, and pepper. Mix until well combined.

Transfer to Baking Dish

Pour the mixture into a greased 9x13 inch casserole dish.

Bake

Bake in the preheated oven for 25-30 minutes or until the cheese is bubbly and golden.

Allow to cool slightly before serving. Enjoy!

Storage and Reheating Tips

If you have leftovers, store them in an airtight container in the refrigerator for up to three days. This casserole can also be frozen, making it an excellent option for meal prep. When freezing, it’s best to do so before baking. Just assemble the casserole and cover it tightly with foil. When you’re ready to enjoy it, let it thaw overnight in the refrigerator before baking as directed.

To reheat, simply place the casserole in a 350°F (175°C) oven and bake until heated through and bubbly. This makes it a practical choice for those who desire delicious, homemade meals without the hassle of daily cooking.

Variations and Add-Ins

Feel free to customize this casserole to your liking! For a bit more crunch, consider adding some sautéed bell peppers or onions to the mixture. You can also mix in some cooked spinach or zucchini for added nutrition and flavor. If you’re a fan of seafood, substituting the shredded chicken with shrimp provides an exciting twist, making it a delightful seafood casserole.

For a cheesy finish, sprinkle extra cheese on top during the last few minutes of baking. This will create a deliciously gooey layer that perfectly complements the spiciness of the sauce and ensures every bite is packed with flavor.

Questions About Recipes

→ Can I use other types of pasta?

Yes, other types of pasta can work, but spaghetti adds a nice texture.

→ Can I make this ahead of time?

Absolutely! Prepare the casserole and refrigerate it for up to 24 hours before baking.